rhabdomyolysis causes

Although mild muscle pain is a relatively common side effect of statins, some people who take statin medications to lower their cholesterol may have severe muscle pain. Myoglobin is … Your kidneys can’t dispose of all the waste without plenty of fluids. Venom from several snakes can cause rhabdomyolysis by direct myotoxicity and/or from muscle ischemia related to coagulopathy 76, 77. … Venom from several snakes can cause rhabdomyolysis by direct myotoxicity and/or from muscle ischemia related to coagulopathy 76, 77. The pathophysiological hallmark of th … Another protein in muscles, called myoglobin, is also released when these cells die. Rhabdomyolysis (often called rhabdo) is a serious medical condition that can be fatal or result in permanent disability. Pediatric rhabdomyolysis is a common diagnosis that pediatricians need to be able to recognize because prompt treatment can prevent potential complications, such as acute kidney injury. Rhabdo occurs when damaged muscle tissue releases its proteins and electrolytes into the blood. Rhabdomyolysis (literally, “dissolution of skeletal muscle”) is a syndrome caused by injury to skeletal muscle and involves leakage of large quantities of potentially toxic intracellular contents into plasma. Rhabdomyolysis can cause muscle pain and weakness. Rhabdomyolysis (RM) was originally described in patients with crush injury, but non-traumatic causes are also common. If you’re starting a new workout routine and doing it gradually, the risk of rhabdomyolysis is extremely low. Wasp stings 78 and spider bites 79 have also been associated with rhabdomyolysis. The causes of rhabdomyolysis; the clinical features and diagnosis of acute kidney injury due to rhabdomyolysis; the management of patients with rhabdomyolysis, including methods to prevent acute kidney injury and related metabolic complications; and the prevention and management of acute compartment syndrome are discussed in detail separately. Rhabdomyolysis (RM) was originally described in patients with crush injury, but non-traumatic causes are also common. Its major causes include trauma, ischemia, drugs, toxins, metabolic disorders, and infections. The subsequent release of intracellular ions, myoglobin, creatine kinase (CK), and urates into the circulation results in electrolyte disturbances, acidaemia, disseminated intravascular coagulation, renal failure, and multi-organ failure. The main symptoms of rhabdomyolysis are muscle aches, muscle weakness, and darkened urine. Your kidneys can’t dispose of all the waste without plenty of fluids. Treat any underlying diseases (e.g., rhabdomyolysis, hyperthyroidism, adrenal insufficiency). Its major causes include trauma, ischemia, drugs, toxins, metabolic disorders, and infections. Model of helical domains in myoglobin. Myoglobin is … The goal is to induce a brisk diuresis to prevent myoglobin precipitation and deposition, which can cause acute kidney injury. Unlike DOMS, rhabdomyolysis is a serious condition that requires medical attention. The goal is to induce a brisk diuresis to prevent myoglobin precipitation and deposition, which can cause acute kidney injury. When muscle tissue dies, electrolytes and large proteins are released into the bloodstream that can cause irregular heart rhythms and seizures, and damage the kidneys. If you’re starting a new workout routine and doing it gradually, the risk of rhabdomyolysis is extremely low. Medications can cause muscle injury and rhabdomyolysis. It results from the death of muscle fibers and release of their contents into the bloodstream. When muscle tissue dies, electrolytes and large proteins are released into the bloodstream that can cause irregular heart rhythms and seizures, and damage the kidneys. The most common causes … This releases creatinine into the blood, causing creatinine levels to rise. Learn more: Mayo Clinic facts about coronavirus disease 2019 (COVID-19) Our COVID-19 patient and visitor guidelines, plus trusted health information Latest on COVID-19 vaccination by site: Arizona patient vaccination updates Arizona, Florida patient vaccination updates Florida, Rochester patient vaccination updates Rochester and Mayo Clinic Health … Definition/Description [edit | edit source]. It can cause kidney damage or failure, and even death. Its major causes include trauma, ischemia, drugs, toxins, metabolic disorders, and infections. Medications can cause muscle injury and rhabdomyolysis. Rhabdomyolysis is the rapid destruction of skeletal muscle resulting in leakage into the urine of the muscle protein myoglobin. Heatstroke can cause rhabdomyolysis, as can a bite from some types of snakes whose venom causes … This releases creatinine into the blood, causing creatinine levels to rise. Another protein in muscles, called myoglobin, is also released when these cells die. Low to moderate doses may be adequate, depending on the severity of the hypercalcemia (e.g., 20-50 mg prednisone daily). Rhabdomyolysis is a condition involving damage to the skeletal muscle or muscles of the body. Rhabdomyolysis is the breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood. Rhabdomyolysis may result from any traumatic or medical injury to the sarcolemma (the myocyte cell membrane) of the skeletal muscle cells. These substances are harmful to the kidney and often cause kidney damage. When muscles are damaged through trauma, drug toxicity, disease, or other causes, the cells release their contents into the blood stream. Model of helical domains in myoglobin. CONTENTS Rapid Reference Pathophysiology Definition & diagnosis Evaluation Treatment Overview Step #1 – Volume resuscitation Step #2 – Insulin Step #3 – Water repletion Rhabdomyolysis Podcast Questions & discussion Pitfalls PDF of this chapter (or create customized PDF) pathogenesis of hyperosmolar hyperglycemic state (HHS) HHS is often triggered by an acute … Causes. Many cases result from crush injuries to the muscles that can be seen in people who have been in vehicle accidents or have suffered other serious trauma. These substances are harmful to the kidney and often cause kidney damage. Rhabdomyolysis is defined as a clinical and biochemical syndrome resulting from skeletal muscle injury that alters the integrity of the muscle cell membrane sufficiently to allow the release of the muscle cell content into the plasma. The risk of rhabdomyolysis with statins is increased in the elderly, with use of interacting medications (eg, fibrates) and hypothyroidism. Rhabdomyolysis (literally, “dissolution of skeletal muscle”) is a syndrome caused by injury to skeletal muscle and involves leakage of large quantities of potentially toxic intracellular contents into plasma. Rhabdomyolysis is the breakdown of damaged skeletal muscle. Although mild muscle pain is a relatively common side effect of statins, some people who take statin medications to lower their cholesterol may have severe muscle pain. Rhabdomyolysis has a variety of causes. The incidence of rhabdomyolysis from all causes is 1.6 per 100,000 person-years 8; the US Food and Drug Administration Adverse Event Reporting System database reports rates of statin-induced rhabdomyolysis of 0.3–13.5 cases per 1,000,000 statin prescriptions. First described in the victims of crush injury during World War II, it is a final pathway of diverse processes and insults. Rhabdomyolysis, which is diagnosed by a serum creatine phosphokinase level more than 10 times the upper limit of normal, may increase the risk of acute renal failure. Pediatric rhabdomyolysis is a common diagnosis that pediatricians need to be able to recognize because prompt treatment can prevent potential complications, such as acute kidney injury. When muscle tissue dies, electrolytes and large proteins are released into the bloodstream that can cause irregular heart rhythms and seizures, and damage the kidneys. Rhabdomyolysis is defined as a pathological condition of skeletal muscle cell damage leading to the release of toxic intracellular material into the blood circulation. Certain medical conditions, however, may cause your urine to become strong- or foul-smelling or may affect the odor of your vulva and vaginal discharge, so that you think your urine smells bad 1 2.A strong urine odor in females can be harmless or the sign of a serious problem 1 2. Rhabdomyolysis (often called rhabdo) is a serious medical condition that can be fatal or result in permanent disability. The pathophysiological hallmark of th … It can cause kidney damage or failure, and even … Low to moderate doses may be adequate, depending on the severity of the hypercalcemia (e.g., 20-50 mg prednisone daily). First described in the victims of crush injury during World War II, it is a final pathway of diverse processes and insults. Rhabdomyolysis. Learn more: Mayo Clinic facts about coronavirus disease 2019 (COVID-19) Our COVID-19 patient and visitor guidelines, plus trusted health information Latest on COVID-19 vaccination by site: Arizona patient vaccination updates Arizona, Florida patient vaccination updates Florida, Rochester patient vaccination updates Rochester and Mayo Clinic … Rhabdomyolysis is a serious condition that can result from severe muscle injury. However, dark brown urine, rusty urine, or coca cola-colored urine can be a sign of rhabdomyolysis, a breakdown of muscle tissue that releases a protein called myoglobin into the bloodstream, leading to possible kidney damage, according to the U.S. National Library of Medicine. Causes Rhabdomyolysis is defined as a clinical and biochemical syndrome resulting from skeletal muscle injury that alters the integrity of the muscle cell membrane sufficiently to allow the release of the muscle cell content into the plasma. These substances are harmful to the kidney and often cause kidney damage. First described in the victims of crush injury during World War II, it is a final pathway of diverse processes and insults. The risk of rhabdomyolysis with statins is increased in the elderly, with use of interacting medications (eg, fibrates) and hypothyroidism. If patients on statins develop myositis (muscle pain, muscle tenderness and weakness) or myalgia then the statin should be … Although mild muscle pain is a relatively common side effect of statins, some people who take statin medications to lower their cholesterol may have severe muscle pain. Causes The most common causes … Unlike DOMS, rhabdomyolysis is a serious condition that requires medical attention. Hospitalization and IV hydration should be the first step in any patient suspected of having myoglobinuria or rhabdomyolysis. Heatstroke can cause rhabdomyolysis, as can a bite from some types of snakes whose venom causes … Rhabdomyolysis: One case study showed that laxative abuse may have induced rhabdomyolysis, causing the rapid deterioration of muscle tissue and the release of a harmful protein into the bloodstream . Some ticks carry a bacteria that causes a serious infection called babesiosis. Rhabdomyolysis: One case study showed that laxative abuse may have induced rhabdomyolysis, causing the rapid deterioration of muscle tissue and the release of a harmful protein into the bloodstream . The risk of rhabdomyolysis with statins is increased in the elderly, with use of interacting medications (eg, fibrates) and hypothyroidism. Rhabdomyolysis is the breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood. Rhabdomyolysis is a serious condition that can result from severe muscle injury. Rhabdomyolysis is when skeletal muscle tissue deteriorates. The incidence of rhabdomyolysis from all causes is 1.6 per 100,000 person-years 8; the US Food and Drug Administration Adverse Event Reporting System database reports rates of statin-induced rhabdomyolysis of 0.3–13.5 cases per 1,000,000 statin prescriptions. The triggers for rhabdomyolysis are extensive, with viruses … Unlike DOMS, rhabdomyolysis is a serious condition that requires medical attention. Rhabdomyolysis is the breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood. Treat any underlying diseases (e.g., rhabdomyolysis, hyperthyroidism, adrenal insufficiency). The death of muscle fibers causes their cells to empty into the … This may then release certain substances into the blood and cause kidney failure. Wasp stings 78 and spider bites 79 have also been associated with rhabdomyolysis. Rhabdomyolysis is a serious, acute condition that results from rapid death of muscle tissue. The most common causes … When the kidneys are unable remove this waste quickly enough, renal (kidney) failure may result. The incidence of rhabdomyolysis from all causes is 1.6 per 100,000 person-years 8; the US Food and Drug Administration Adverse Event Reporting System database reports rates of statin-induced rhabdomyolysis of 0.3–13.5 cases per 1,000,000 statin prescriptions. It usually happens when someone jumps right into heavy activity without building up to it. Low to moderate doses may be adequate, depending on the severity of the hypercalcemia (e.g., 20-50 mg prednisone daily). However, dark brown urine, rusty urine, or coca cola-colored urine can be a sign of rhabdomyolysis, a breakdown of muscle tissue that releases a protein called myoglobin into the bloodstream, leading to possible kidney damage, according to the U.S. National Library of Medicine. Model of helical domains in myoglobin. Heatstroke can cause rhabdomyolysis, as can a bite from some types of snakes whose venom causes … Causes of rhabdomyolysis include: High-intensity exercise: Jumping into an exercise program too fast can lead to rhabdomyolysis when muscles don’t have time to heal after an intense workout. It usually happens when someone jumps right into heavy activity without building up to it. Certain medical conditions, however, may cause your urine to become strong- or foul-smelling or may affect the odor of your vulva and vaginal discharge, so that you think your urine smells bad 1 2.A strong urine odor in females can be harmless or the sign of a serious problem 1 2. Myoglobin is … Common causes of rhabdomyolysis include trauma, burns, prolonged immobilization, excessive exercise, medications, drug abuse, other diseases, snake bites, and spider bites. It results from the death of muscle fibers and release of their contents into the bloodstream. Rhabdomyolysis is a serious, acute condition that results from rapid death of muscle tissue. If patients on statins develop myositis (muscle pain, muscle tenderness and weakness) or myalgia then the statin should be … Pediatric rhabdomyolysis is a common diagnosis that pediatricians need to be able to recognize because prompt treatment can prevent potential complications, such as acute kidney injury. A high index of suspicion is necessary to allow prompt recognition and treatment to avoid the development of acute renal failure (ARF) and need for … Causes of rhabdomyolysis include: High-intensity exercise: Jumping into an exercise program too fast can lead to rhabdomyolysis when muscles don’t have time to heal after an intense workout. Rhabdomyolysis is defined as a pathological condition of skeletal muscle cell damage leading to the release of toxic intracellular material into the blood circulation. Rhabdomyolysis occurs when muscle tissue breaks down, releasing into the blood stream. Rhabdomyolysis (literally, “dissolution of skeletal muscle”) is a syndrome caused by injury to skeletal muscle and involves leakage of large quantities of potentially toxic intracellular contents into plasma. The subsequent release of intracellular ions, myoglobin, creatine kinase (CK), and urates into the circulation results in electrolyte disturbances, acidaemia, disseminated intravascular coagulation, renal failure, and multi-organ failure. If you’re starting a new workout routine and doing it gradually, the risk of rhabdomyolysis is extremely low. This condition is called rhabdomyolysis, or "rhabdo," and it can turn your urine brown. Rhabdomyolysis is a medical condition associated with heat stress and prolonged physical exertion, resulting in the rapid breakdown, rupture, and death of muscle. This intense pain may be a symptom of rhabdomyolysis (rab-doe-my-OL-ih-sis), a rare condition that causes … When muscles are damaged through trauma, drug toxicity, disease, or other causes, the cells release their contents into the blood stream. Muscle breakdown causes the release of myoglobin into the bloodstream. Hospitalization and IV hydration should be the first step in any patient suspected of having myoglobinuria or rhabdomyolysis. 9 The literature suggests several risk factors that may predispose a person to develop statin-induced rhabdomyolysis, … Classically, RM is treated with Rhabdomyolysis is the rapid destruction of skeletal muscle resulting in leakage into the urine of the muscle protein myoglobin. A high index of suspicion is necessary to allow prompt recognition and treatment to avoid the development of acute renal failure (ARF) and need for hemodialysis. Rhabdomyolysis is a potentially life-threatening syndrome resulting from the breakdown of skeletal muscle fibers with leakage of muscle contents into the circulation. Rhabdomyolysis is a potentially life-threatening syndrome resulting from the breakdown of skeletal muscle fibers with leakage of muscle contents into the circulation. Learn more: Mayo Clinic facts about coronavirus disease 2019 (COVID-19) Our COVID-19 patient and visitor guidelines, plus trusted health information Latest on COVID-19 vaccination by site: Arizona patient vaccination updates Arizona, Florida patient vaccination updates Florida, Rochester patient vaccination updates Rochester and Mayo Clinic Health … The main symptoms of rhabdomyolysis are muscle aches, muscle weakness, and darkened urine. Certain medical conditions, however, may cause your urine to become strong- or foul-smelling or may affect the odor of your vulva and vaginal discharge, so that you think your urine smells bad 1 2.A strong urine odor in females can be harmless or the sign of a serious problem 1 2. Many cases result from crush injuries to the muscles that can be seen in people who have been in vehicle accidents or have suffered other serious trauma. Causes. Severe dehydration and overheating: Heat causes faster muscle breakdown. Rhabdomyolysis occurs when muscle tissue breaks down, releasing into the blood stream. The death of muscle fibers causes their cells to empty into the … Rhabdomyolysis is the rapid destruction of skeletal muscle resulting in leakage into the urine of the muscle protein myoglobin. Causes of rhabdomyolysis include: High-intensity exercise: Jumping into an exercise program too fast can lead to rhabdomyolysis when muscles don’t have time to heal after an intense workout. However, dark brown urine, rusty urine, or coca cola-colored urine can be a sign of rhabdomyolysis, a breakdown of muscle tissue that releases a protein called myoglobin into the bloodstream, leading to possible kidney damage, according to the U.S. National Library of Medicine. Definition/Description [edit | edit source]. Common causes of rhabdomyolysis include trauma, burns, prolonged immobilization, excessive exercise, medications, drug abuse, other diseases, snake bites, and spider bites. First described in the victims of crush injury during World War II, it is a final pathway of diverse processes and insults. Rhabdomyolysis is a condition in which skeletal muscle tissue dies, releasing substances into the blood that cause kidney failure. Rhabdomyolysis (literally, “dissolution of skeletal muscle”) is a syndrome caused by injury to skeletal muscle and involves leakage of large quantities of potentially toxic intracellular contents into plasma. Muscle breakdown causes the release of myoglobin into the bloodstream. Rhabdomyolysis can cause muscle pain and weakness. Rhabdomyolysis is a rare condition characterized by the death of muscle cells. This intense pain may be a symptom of rhabdomyolysis (rab-doe-my-OL-ih-sis), a rare condition that causes … Rhabdomyolysis. Rhabdomyolysis is a serious syndrome due to a direct or indirect muscle injury. Rhabdomyolysis has many causes. Rhabdomyolysis (literally, “dissolution of skeletal muscle”) is a syndrome caused by injury to skeletal muscle and involves leakage of large quantities of potentially toxic intracellular contents into plasma. Treat any underlying diseases (e.g., rhabdomyolysis, hyperthyroidism, adrenal insufficiency). A high index of suspicion is necessary to allow prompt recognition and treatment to avoid the development of acute renal failure (ARF) and need for hemodialysis. Rhabdomyolysis is a rare condition characterized by the death of muscle cells. Rhabdomyolysis, which is diagnosed by a serum creatine phosphokinase level more than 10 times the upper limit of normal, may increase the risk of acute renal failure. Causes. Rhabdomyolysis is a serious syndrome due to a direct or indirect muscle injury. The triggers for rhabdomyolysis are extensive, with viruses being the … This intense pain may be a symptom of rhabdomyolysis (rab-doe-my-OL-ih-sis), a rare condition that causes … Some ticks carry a bacteria that causes a serious infection called babesiosis. When muscles are damaged through trauma, drug toxicity, disease, or other causes, the cells release their contents into the blood stream. It usually happens when someone jumps right into heavy activity without building up to it. If patients on statins develop myositis (muscle pain, muscle tenderness and weakness) or myalgia then the statin should be … Rhabdomyolysis has many causes. When the kidneys are unable remove this waste quickly enough, renal (kidney) failure may result. Rhabdomyolysis is defined as a pathological condition of skeletal muscle cell damage leading to the release of toxic intracellular material into the blood circulation. We are open for safe in-person care. Rhabdomyolysis is defined as a clinical and biochemical syndrome resulting from skeletal muscle injury that alters the integrity of the muscle cell membrane sufficiently to allow the release of the muscle cell content into the plasma. Rhabdomyolysis is a medical condition associated with heat stress and prolonged physical exertion, resulting in the rapid breakdown, rupture, and death of muscle. Ordinarily, urine has little to no odor 1 2. Rhabdomyolysis may result from any traumatic or medical injury to the sarcolemma (the myocyte cell membrane) of the skeletal muscle cells. Rhabdomyolysis may result from any traumatic or medical injury to the sarcolemma (the myocyte cell membrane) of the skeletal muscle cells. Rhabdomyolysis is the breakdown of damaged skeletal muscle. Venoms, toxins, pesticides, and poisons are relatively rare causes of rhabdomyolysis. Rhabdomyolysis has a variety of causes. Common causes of rhabdomyolysis include trauma, burns, prolonged immobilization, excessive exercise, medications, drug abuse, other diseases, snake bites, and spider bites. The triggers for rhabdomyolysis are extensive, with viruses … Muscle breakdown causes the release of myoglobin into the bloodstream. Rhabdomyolysis: One case study showed that laxative abuse may have induced rhabdomyolysis, causing the rapid deterioration of muscle tissue and the release of a harmful protein into the bloodstream . Rhabdomyolysis, which is diagnosed by a serum creatine phosphokinase level more than 10 times the upper limit of normal, may increase the risk of acute renal failure. Ordinarily, urine has little to no odor 1 2. Rhabdomyolysis can cause muscle pain and weakness. Medications can cause muscle injury and rhabdomyolysis. The pathophysiological hallmark of th … Some ticks carry a bacteria that causes a serious infection called babesiosis. The causes of rhabdomyolysis; the clinical features and diagnosis of acute kidney injury due to rhabdomyolysis; the management of patients with rhabdomyolysis, including methods to prevent acute kidney injury and related metabolic complications; and the prevention and management of acute compartment syndrome are discussed in detail separately. Rhabdomyolysis is a serious syndrome due to a direct or indirect muscle injury. … Another protein in muscles, called myoglobin, is also released when these cells die. Rhabdomyolysis is a serious condition that can result from severe muscle injury. Wasp stings 78 and spider bites 79 have also been associated with rhabdomyolysis. Venoms, toxins, pesticides, and poisons are relatively rare causes of rhabdomyolysis. Classically, RM is treated with Rhabdomyolysis is a condition in which skeletal muscle tissue dies, releasing substances into the blood that cause kidney failure. Steroid is useful for selected causes of hypercalcemia (e.g., sarcoidosis, lymphoma). Ordinarily, urine has little to no odor 1 2. The main symptoms of rhabdomyolysis are muscle aches, muscle weakness, and darkened urine. This condition is called rhabdomyolysis, or "rhabdo," and it can turn your urine brown. Your kidneys can’t dispose of all the waste without plenty of fluids. Severe dehydration and overheating: Heat causes faster muscle breakdown. Rhabdomyolysis is a serious, acute condition that results from rapid death of muscle tissue. Rhabdomyolysis is the breakdown of damaged skeletal muscle. It can cause kidney damage or failure, and even death. Rhabdomyolysis (literally, “dissolution of skeletal muscle”) is a syndrome caused by injury to skeletal muscle and involves leakage of large quantities of potentially toxic intracellular contents into plasma. Rhabdomyolysis is a potentially life-threatening syndrome resulting from the breakdown of skeletal muscle fibers with leakage of muscle contents into the circulation. Definition/Description [edit | edit source]. This condition is called rhabdomyolysis, or "rhabdo," and it can turn your urine brown. Steroid is useful for selected causes of hypercalcemia (e.g., sarcoidosis, lymphoma). Rhabdo occurs when damaged muscle tissue releases its proteins and electrolytes into the blood. The death of muscle fibers causes their cells to empty into the … When the kidneys are unable remove this waste quickly enough, renal (kidney) failure may result. Venom from several snakes can cause rhabdomyolysis by direct myotoxicity and/or from muscle ischemia related to coagulopathy 76, 77. Many cases result from crush injuries to the muscles that can be seen in people who have been in vehicle accidents or have suffered other serious trauma. Causes First described in the victims of crush injury during World War II, it is a final pathway of diverse processes and insults. Rhabdo occurs when damaged muscle tissue releases its proteins and electrolytes into the blood. Rhabdomyolysis occurs when muscle tissue breaks down, releasing into the blood stream. It results from the death of muscle fibers and release of their contents into the bloodstream. Rhabdomyolysis is a medical condition associated with heat stress and prolonged physical exertion, resulting in the rapid breakdown, rupture, and death of muscle. The causes of rhabdomyolysis; the clinical features and diagnosis of acute kidney injury due to rhabdomyolysis; the management of patients with rhabdomyolysis, including methods to prevent acute kidney injury and related metabolic complications; and the prevention and management of acute compartment syndrome are discussed in detail separately. Rhabdomyolysis (often called rhabdo) is a serious medical condition that can be fatal or result in permanent disability. Severe dehydration and overheating: Heat causes faster muscle breakdown. This releases creatinine into the blood, causing creatinine levels to rise. Venoms, toxins, pesticides, and poisons are relatively rare causes of rhabdomyolysis. We are open for safe in-person care. Rhabdomyolysis is a condition involving damage to the skeletal muscle or muscles of the body. Rhabdomyolysis has many causes. Steroid is useful for selected causes of hypercalcemia (e.g., sarcoidosis, lymphoma). Rhabdomyolysis is a condition involving damage to the skeletal muscle or muscles of the body. We are open for safe in-person care. First described in the victims of crush injury during World War II, it is a final pathway of diverse processes and insults. Rhabdomyolysis. Hospitalization and IV hydration should be the first step in any patient suspected of having myoglobinuria or rhabdomyolysis. Rhabdomyolysis is a rare condition characterized by the death of muscle cells. The goal is to induce a brisk diuresis to prevent myoglobin precipitation and deposition, which can cause acute kidney injury. Rhabdomyolysis (RM) was originally described in patients with crush injury, but non-traumatic causes are also common. The subsequent release of intracellular ions, myoglobin, creatine kinase (CK), and urates into the circulation results in electrolyte disturbances, acidaemia, disseminated intravascular coagulation, renal failure, and multi-organ failure. Rhabdomyolysis has a variety of causes.

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